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Raphaela Goldbach-Mansky

Country: Niaid, National Institutes of Health (NIH), United States
Raphaela Goldbach-Mansky

Dr. Raphaela Goldbach-Mansky is the Chief of the Translational Autoinflammatory Diseases Section (TADS) in the Laboratory of Clinical Immunology and Microbiology (LCIM) at NIAID at the NIH. Dr. Goldbach-Mansky’s translational research program focuses on clinical and translational studies in children with early-onset autoinflammatory diseases. Her research applies an integrative approach to characterize the genetic and molecular causes of autoinflammatory diseases and to design targeted treatment studies to investigate the role of specific inflammatory pathways in the pathogenesis of autoinflammatory diseases. Her studies in patients with NOMID and DIRA established targeted treatments with IL-1 inhibitors as standard of care and led to FDA approval of anakinra for NOMID and anakinra and rilonacept in DIRA. Her more recent translational and interventional studies focus on understanding the pathogenic role for Interferons in autoinflammatory diseases patients with chronic IFN signatures, including CANDLE, SAVI and NEMO-NDAS, and on additional pathways that amplify innate immune dysregulation and drive sterile inflammation. Dr. Goldbach-Mansky is a co-founder of the Translational autoinflammatory research network (TARN) to promote translational research in patients with rare autoinflammatory diseases.

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